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Inhaled Antibiotics in Bronchiectasis and Cystic Fibrosis (iABC)

The aims of the iABC project are:

  • To determine the initial therapeutic efficacy of TIP in BE patients
  • To explore novel endpoints (microbiome, LCI and CT imaging) for clinical trials in both CF and BE
  • To build repositories of clinical respiratory isolates and sputum biobanks for use in future research
  • To develop an EU-wide prospective registry of BE in all EU and EU-associated countries to facilitate better clinical care and future research into this disease
  • To develop an inhaled formulation and dispersion device for POL7080, a novel antibiotic with activity against Pseudomonas aeruginosa.
  • To determine the pharmacokinetics and safety of POL7080 in CF patients and provide efficacy data.
  • To evaluate the safety and tolerability of the OSCN- and LF compounds of ALX-009, separately and combined at different doses.
  • To evaluate the clinical efficacy of different doses and different administration schedules of ALX-009 and the contribution of each of its compounds (OSCN/LF) when administered separately in CF patients in order to define an optimal treatment regimen.
  • To determine the therapeutic efficacy of QBW251 (a CFTR potentiator) in patients with BE